A comparison between intravenous metoprolol and labetalol in prevention of cardiovascular stress response to laryngoscopy and intubation

Abstract

Introduction: A prospective, randomized, double blind, clinical study was designed to compare intravenous metoprolol 30 µg/kg versus intravenous labetalol 0.2 mg/kg single dose given 5 min prior to intubation in for prevention of cardiovascular stress response to laryngoscopy and intubation in patients undergoing spine surgeries under general anesthesia.
Methodology: Sixty ASA grade I patients of either sex , comprising age group of 25-50 years , undergoing elective spine surgeries under general anesthesia were randomly distributed in two equal groups. Inj metoprolol hydrochloride 30 µg/kg in Group M and inj labetalol 0.2 mg/kg in Group L respectively were given intravenously 5 min prior to induction. Heart rate, systolic, diastolic and MBP recorded at different time intervals before and after intubation.
Results: Significant rise noted in heart rate, systolic, diastolic and MBP immediately after intubation in both groups though less in Group L that remained up to 2 min; returned to baseline between 2 to 5 min and became significantly lower than baseline at 5 min and onwards.
Conclusion: Labetalol is superior to metoprolol in attenuating the cardiovascular stress response to laryngoscopy and intubation.