Effects of nicardipine versus diltiazem on catecholamine secretion and renin-angiotensinaldosterone system during propofol-fentanylnitrous oxide anesthesia

Abstract

Background and aim: Nicardipine and diltiazem, used to decrease blood pressure, have different actions on hemodynamics and hormonal response during inhalational anesthesia. However, there are no studies to compare these effects of nicardipine and diltiazem in propofol-fentanyl-nitrous oxide anesthesia. Therefore, we performed this study to compare the effects of nicardipine and diltiazem on hemodynamics, plasma concentrations of catecholamines and renin-angiotensin-aldosterone activity in propofol-fentanyl-nitrous oxide anesthesia.