The efficacy of dexmedetomidine on lung injury induced by renal ischemia/reperfusion indiabetic rats

  • Seyfi Kartal Department of Anesthesiology and Reanimation, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.
  • Gülay Kip Department of Anesthesiology and Reanimation, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.
  • Ayşegül Küçük Department of Anesthesiology and Reanimation, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.
  • Ali Atan Department of Anesthesiology and Reanimation, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.
  • Özlem Erdem Department of Anesthesiology and Reanimation, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.
  • Mustafa Kavutçu Department of Anesthesiology and Reanimation, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.
DOI: https://doi.org/10.35975/apic.v24i3.1281
Keywords: Dexmedetomidine, ischemia-reperfusion, lung, renal, diabetes

Abstract

Ischemia-reperfusion injury is a complex, which causes cell damage. In this study, we aimed to investigate the protective effects of dexmedetomidine on lung in the renal IR model in diabetic rats.

After approval of the ethics committee, diabetes was induced by streptozocin (55 mg/kg) and then 24 Wistar Albino rats were randomly divided into 4 groups. Diabetic control group (group DC), diabetic dexmedetomidine (group DD), diabetic ischemia-reperfusion (group DIR), diabetic ischemia-reperfusion - dexmedetomidine (group DIR-D).

Published
08-07-2020
Issue
Vol 24 No 3 (2020): July-Sep
Section
ORIGINAL RESEARCH