Effect of propofol on endogenous morphine in serum

Abstract

Background & Objective: Studies have indicated that there is alteration of endogenous morphine after surgical interventions. As surgical interventions either clinical or experimental are carried out under anaesthesia. So, it cannot be concluded that the altered endogenous morphine is due to only surgical trauma. The research was, is there any anaesthetic effect on the endogenous morphine?  Objective of the current study was to determine any effect of propofol anaesthesia on the endogenous morphine.
Methodology: Young male rats were injected either propofol anesthesia or intralipid control and scarified at day 1 and      day 3 to obtain blood and serum samples. Endogenous morphine was quantified in the samples by using a morphine specific enzyme-linked immunosorbent assay kit. Results: one way ANVOA showed a significant effect of treatment at day 1 between propofol and intralipidic control (p < 0.05). There was also significant effect of propofol between days of treatment with propofol (p < 0.05) but not with intralipid controls (p < 0.05).
Conclusion: The current study showed that propofol anaesthesia increases the level of endogenous morphine at day 1 of the treatment. This increase of endogenous morphine till day 1 might show a protective effect as analgesic in reaction to propofol injection. However, this effect was diminished at day 3 of the treatment.
Key words: ; ; ; ; 
Citation: Rafiq M. Effect of propofol on endogenous morphine in serum. Anaesth Pain & Intensive Care 2018;22(4):452-455
Received: 25 August 2018, Reviewed: 29 September, 23 October 2018, Corrected: 26 October 2018, Reviewed: 27 October 2018, Accepted: 01 November 2018