Category : Case Reports

Lower limb weakness and paresthesia after combined spinal epidural anesthesia for abdominal hysterectomy: a report of three cases

Udita Naithani, MD*, DevendraVerma, MD*, Dr.Rajkumar S, MBBS**, Pradeep D. S., MBBS**

*Associate Professor; **Senior Registrar in Anaesthesia

Department of Anesthesiology, R.N.T Medical College, Udaipur, Rajastan, (India)

Correspondence: Dr.Rajkumar S, Room No. 3, PG Men’s Hostel, RNT Medical College, Udaipur, Rajastan, 313001(India); E-mail: dr.rajkumar@ymail.com

ABSTRACT

Neurological deficits are the rare but unacceptable complications of neuraxial blockade. We report three casesof vaginal hysterectomy performed under combined spinal epidural anesthesia (CSE) using 3 ml of 0.5% hyperbaric bupivacaine (15mg) in subarachnoid space followed by epidural analgesia top up after wearing off of spinal anesthesia. One patient complained of unilateral paresthesia and numbness on left thigh with no motor involvement in the evening postoperatively, two patients developed bilateralparesthesia and numbness over anterior thigh and knees and motor weakness in both lower limbs on next day morning. Epidural catheter was removed immediately and treated with oral tab prednisolone and tab methylcobalamin. All patients had complete recovery andwere discharged after a week.Unrecognised mechanical irritationof the nerve roots by epidural catheter is thought to be the cause.We conclude that patients with epidural catheter should be monitored and onappearance of any neurological symptomsthe catheter be removed to prevent permanent neurological sequelae.

Keywords:Anesthesia, Epidural;Anesthesia, Spinal; complications; Paresthesia;Somatosensory Disorders; Sequelae

Citation:Naithani U, Verma D, Rajkumar S, Pradeep DS. Lower limb weakness and paresthesia after combined spinal epidural anesthesia for abdominal hysterectomy: a report of three cases. Anaesth Pain & Intensive Care 2015;19(2):187-91

INTRODUCTION

In the recent years combined spinal epidural(CSE) anesthesia has become more popular as it provides anesthesia as quickly as single shot subarachnoid block, allows intraoperative epidural supplementation and prolonged postoperative analgesia.

Incidence of neurologic injury has been reported to be 0 to 0.16% of all spinal and epidural anesthesia;persistent paresthesia and limited motor weakness being the most common presentation of neurological sequelae.1 Higher incidence of paresthesia during CSE (0.9 – 11%)is a recognised factor.2

Neurological complications following neuraxialanesthesiacan be caused by hematoma formation, infection, traumatic placement and drug toxicity. Other contributing factors are spinal cord ischemia due to the use of vasoconstrictors, prolonged hypotension and lithotomy position.1

The cases of sensory and motor impairment following epidural catheterisation have been reported. Some showed complete recovery after catheter removal;3,4 however, in few patients sensorimotor symptoms persisted.5,6

We report a case series of three female patients who underwent vaginal hysterectomy in lithotomy position under CSE anesthesia.They developed paresthesiae, numbness and motor weakness of lower limb within 24 hours postoperatively. Possible mechanisms, treatment and outcome are discussed.

CASE REPORT 1

A 62 year, 60 Kg female patient of ASA I,  haduterovaginalprolapse with cystocele and was taken for vaginal hysterectomy with pelvic floor repair. Pre-anesthetic evaluation including history, physical examination and investigations were unremarkable. Patient wasshifted to OR with 8 hour fasting status and preloaded with 500ml Ringer lactatesolution via 18G peripheral IV cannula.Standard ASA monitoring was done usingnoninvasive blood pressure, pulseoximetry and electrocardiography. After recording baseline vitals, patient was placed in right lateral position. Tuffier’s line (line crossing anterior superior iliac spine) was identified and taken as a landmark to correspond to L4-5 interspace. Under aseptic precautions skin was infiltrated with 2% lidocaine (3ml) using 5 ml disposable syringe with 24G needle in midline. Epidural space was identified with 18G Tuohy needle using loss of resistance to normal saline techniquein a single attempt. Then a 27G Whitacre needle was passed via Tuohy needle to reach subarachnoid space.It took three attempts to locate subarachnoid space and get the free flow of CSF, then 3 ml of 0.5% hyperbaric bupivacaine(15 mg) was injected in subarachnoid space. Spinal needle was removed and 18G epidural catheter was inserted upto5cm into the epidural space. Sterile dressing was applied, catheter was fixed and the patient was turned supine. After 5 min, sensory level of T6 was achieved and she was placed in lithotomy position. Surgery was allowed to start after 10 min of spinal injection.Surgery lasted for 60 min and a total of 1500 ml Ringer’s Lactate solution was infused. As per institutional protocol ofpost-operative epidural analgesia, 50 µg fentanyl diluted in 5 ml was given through epidural catheter at the end of surgery, which was to be repeated 12 hourly till 48 hours.The patient recovered from spinal anesthesia completely in 3 hours.

When patient was attended for epidural drug administration in the evening, she complained of feeling of tingling and numbness in right anterior thigh and around the right knee. Motor examination was normal.Epidural catheter was removed and she was assured regarding reversible nature of the symptoms andtreated with oral prednisolone 20 mg twice daily and methylcobalamin 1500 µg once daily for 5 days. She showed gradual recovery starting on next day of the treatment, recovered completely over 4 days and was discharged on 7th day.

CASE REPORT 2

A 50 years old 55 Kg patient underwent vaginal hysterectomy under CSE as described in case report 1. In this case all steps of CSE procedure were completed easily in single attempt and surgery lasted for 70 min. Sensory and motor recovery occurred completely in three and a half hours.She was pain and symptom free in the evening when she received booster dose of fentanylthrough epidural catheter. On the next morning when she tried to standup on the floor, she could not and fell down. On examination power of hip flexors was found grade 1 and that of knee extensorsto be grade 2. There was tingling and numbness around both of her knees and anterior aspect of thighs. Epidural catheter was removed and treated with oral steroid and methylcobalamin for 5 days as in case 1. Signs of recovery started within 6 hours and she completely recovered over 5 days and was discharged after 7 days.

CASE REPORT 3

A 40 years old 50 Kg female patient underwent vaginal hysterectomy under CSE as described above. In this case also, all steps of CSE procedure were performed in single attempt and the surgery lasted for 75 min and she recovered completely from spinal anesthesia in 4 hours.She received two doses of 50 µg fentanyl diluted in 5 mlthrough epidural catheter on that day. On next day morning, she complained of bilateral numbness on thighs and knees. Neurological examination revealed hypoesthesia over anterior side of thighs bilaterally and around the knee joints. Bilateral knee jerks were absent. Ankle jerks were normal. Power of hip flexors and knee extensors was grade 3. Epidural catheter was removed and steroids andmethylcobalamin were started.She recovered completely over 5 days and was discharged after 7 days.

In all the three cases CSE block was performed by II year resident anesthesiologist, who was well experienced with CSE technique, under direct supervision of consultant. None of the patients was on anticoagulation treatment and coagulation profiles were all normal. None of the patients complained of any paresthesia during epidural catheter placement or spinal needle placement. All patients received 50 µg fentanyl diluted in 5 ml normal saline, via epidural catheter at the end of surgery. Case 1 received only single dose, while case 2 and 3 also received the second doses in the evening. After removal of the epidural catheter in all of the three patients, postoperative pain was managed with inj.  diclofenac 75 mg IM and inj. tramadol 100 mg IV infusion was given as rescue analgesic as per institutional protocol of acute pain services.

DISCUSSION

Needle or indwelling catheter induced trauma and local anesthetic neurotoxicity have been described to be the etiology of most of the neurological complications following neuraxial block. Other significant causes described are infections, hematoma, transient neurological symptoms (TNS), lithotomy position, etc.1

In our present case series most likely explanation of sensory and motor symptoms seems to be mechanical irritation of the nerve roots by epidural catheter, which remained unrecognised during placement because of prior spinal anesthesia in CSE. It has been reported that if paresthesia occurs during needle or catheter placement there is significantly increased risk of persistent paresthesiaafterwards (P<0.001). In the single space, needle through needle technique of CSE, the insertion of epidural catheter after administration of spinal local anesthetics may prevent identification of paresthesia that may warn the anesthesiologist about catheter misplacement.2

We kept our first diagnosis as catheter impinging on nerve roots, which was removed immediately as neurological symptoms appeared. Steroids and methylcobalamin were administered for treatment as described by others.7Corticosteroids have direct anti-inflammatory effects, reducing the tissue concentration of inflammatory mediators that activate nociceptors.  They also reduce the aberrant firing that can originate from sites of nerve injury.

One important limitation of our case series was that MRI was not done to reach at definite diagnosis,as economic constraints remain a limiting factor to get MRI in every suspected case. We decided to proceed for MRI and neurologist opinion if the symptoms did not recover or got worst.

Hematomaformation is a rare (<1 in 150,000) complication of spinal or epidural anesthesia.Patients with hematoma generally do not recover from spinal anesthesia, persistent motor weakness is most common presentation and they need emergency surgical decompression. We excluded spinal/epidural hematoma in these cases without MRI because our cases showed complete recovery from spinal anesthesia in 3-4 hours, neurological symptoms were mainly sensory with mild motor weakness in two patients and all showed complete recovery after catheter removal.

Similar to our cases Zeidanet al4 described a case of transient postoperative neurological symptoms in a 6 year old male child who underwent radical nephrectomy. Under general anesthesia, epidural catheterisation was done for intra and postoperative analgesia using bupivacaine and morphine. Next morning on 1st postoperative day, he had severe pain in the right groin radiating to anterior surface of the thigh(L2 dermatome) with no motor block. The epidural catheter was removed and a complete neurological recovery was seen within 24 hrs. Mechanical irritation of the nerve root by the epidural catheter due to its longer length was described as the most likely explanation. The length of the epidural catheter introduced into the epidural space (5 cm) was too long for the child and the pain or paresthesia elicited during needle or catheter misplacement may have been hidden by general anesthesia. In our three cases epidural catheter was inserted for 5cm in epidural space which is not too long for adults8.

As per institutional protocol Tuffier’s line was used as an anatomical landmark technique for identification of intervertebral space. There is evidence that using Tuffiers line as a landmark may be misleading and unintentional cephalad needle insertion may occur damaging the cauda equina nerves or conus medullaris. Ultrasound guided space identification reduces chances of error. However we do not have ultrasound guidance as our hospital is in tribal area.

If the needle is off midline, nerve roots may be injured.  Once mechanical damage has occurred, the spinal cord is more susceptible to further damage by agents that would under normal circumstances not be regarded as noxious,e.g.localanesthetics and epinephrine. However, in our case series symptoms of patients were not suggestive of cauda equina syndrome which include severe back pain, saddle anesthesia involving S3,4,5, bladder and bowel incontinence, sciatica type of pain including perineum, external genitalia, anus, lower limb paraplegia, absent ankle reflex, anal reflex and bulbocavernous reflex.9

 Another differential diagnosis could be transient neurological symptoms (TNS) which is defined as pain and / or dysesthesia in the buttocks or legs following spinal anesthesia, with an incidence of 0 % to 37 %,  with repeated high doses of lidocaine and tetracaine rather than bupivacaine.1 We used bupivacaine in spinal anesthesia which is less associated with TNS. Local anesthetics injected into epidural space may undergo transmeningeal transfer into the CSF mostly via the arachnoid villi in the dural cuff region. Repeated injections or continuous infusions may result in increased intrathecal concentration of the local anesthetic in the CSF causing this neurotoxic effect even after epidural analgesia.10In our cases, we did not use local anesthetics in epidural analgesia excluding the drug toxicity as a cause of TNS. We used fentanyl for epidural analgesia. A variety of neurological symptoms after epidural and intrathecal fentanyl have been reported but they were dysphagia, perioral numbness, Horner’s syndrome, nystagmus, claw hand etc. Thesesymptoms were attributed to cephalad spread of fentanyl exhibiting local anesthetic effect by reversible blockade of voltage gated sodium channels.11

Another important differential diagnosis could be prolonged lithotomy positionunder regional anesthesia that had been blamed for femoral neuropathy and TNS. In this position there is flexion abduction and external rotation at hips, thus pressing the stretched inguinal ligament. Compression of its blood supply may lead to local ischemia of nerve trunk. Stretching of the lumbosacral nerves, render them vulnerable to the toxic potential of local anesthetics. Gupta et al7 described two cases of vaginal hysterectomy in epidural and spinal anesthesia lasting for 3hours 30 min and 2hoursrespectively, who developed bilateral numbness andweakness of lower limb on 2nd postoperative day. They were also treated successfully with methylcobalamin, amitryptilineand corticosteroids. They attributed neurological sequelae to prolonged lithotomy position causing femoral neuropathy. In our cases lithotomy position cannot be the sole etiological factor for the neurological symptoms as lithotomy postion lasted only for 60 – 75 min.

Permanent neurological injuries have also been reported after spinal / epidural anesthesia. Wilkinson reported three cases who sustained intrinsic spinal cord lesions after attempted epidural catheterisation. In each case there was an early onset of motor and sensory impairment after the procedure and MRI demonstrated similar, extensive, paracentral, high signal intensity lesions within the cord on T2 weighted images. They proposed that the most likely cause of these lesions was direct trauma to the spinal cord during the procedure and subsequent injection of fluid into the spinal cord producing localised hydromyelia. The prognosis in each case was for a gradual recovery of motor function but spinothalamic sensory impairment and severe spontaneous pain over the affected area persisted.6

In our three cases, as the neurological symptoms appeared, prompt removal of catheter and early treatment prevented the development of permanent neurological damage.Laboratory studies have demonstrated demyelination and inflammation adjacent to the catheter tract in both the spinal root and cord of rats following placement of indwelling subarachnoid catheters.12

CONCLUSION

We conclude that postoperative epidural analgesia administered via single space needle through needle technique of CSE should be carefully monitored for development of sensory and motor symptoms in postoperative periodbecause in these patients insertion of epidural catheter after administration of spinal local anesthetics may prevent identification of paresthesias that may warn about catheter misplacement.If neurological symptoms arise postoperatively, catheter should be removed immediately to prevent permanent neurological sequelae. MRI should be done to confirm diagnosis.  Prior to epidural catheter placement, patients should be well informed regarding possible neurological complications and consent should be obtained to fulfil medicolegalrequirements.

REFERENCES

  1. Horlocker TT, Wedel DJ. Neurologic complications of spinal and epidural anaesthesia. RegAnesth Pain Med 2000;25:83-98
    [PubMed]
  1. Simsa J. Use of 29 G spinal needles and a fixation device with combined spinal epidural technique.ActaAnaesthesiolScand 1994;38:439-41
    [PubMed]
  1. Singh R, Bhattacharya A. Transient radicular pain following epidural catheter insertion. Indian JAnaesth 2002;46:384-385
  2. Zeidan A, Narchi P, Goujard E, Benhamou D. Postoperative nerve irritation syndrome after epidural analgesia in a six year old child. Br J Anaesth2004;92:146-8
    [PubMed][Free full text]
  1. Hetts SW, Narvid J, Singh T, Meagher S, Corcoran K, Higashida RT, et al. Association between lumbar epidural injection and development of acute paraparesis in patients with spinal dural arteriovenous fistulas. Am J Neuroradiol 2007;28:581-83
    [PubMed][Free full text]
  1. Wilkinson P, Valentine A, Gibbs JM. Intrinsic Spinal cord lesions complicating epidural anaesthesia and analgesia:report of three cases. J NeurolNeurosurg Psychiatry 2002;72:537-539
    [PubMed][Free full text]
  1. Gupta R, Valecha V, Walia SS. Femoral neuropathy after lithotomy position- Its treatment modalities. Indian J Anaesth 2006;50:143-144
    [Online]
  1. Beilin Y, Bernstein HH, Zucker- Pinchoff B. The optimal distance that a multiorifice epidural catheter should be threaded into the epidural space. AnesthAnalg 1995;81:301-4
    [PubMed]
  1. Gardner A, Gardner E, Morley T. Cauda equina syndrome: a review of the current clinical and medico-legal position. Eur Spine J. 2011; 20:690–697.
    [PubMed][Free full text]doi: 10.1007/s00586-010-1668-3.
  2. Bourlon-Figuet S, Dubousset AM, Benhamou D, Mazoit JX. Transient neurologic symptoms after epidural analgesia in a five year- old. AnesthAnalg 2000; 91:856-7
    [PubMed]
  3. Anson JA, McQuillan PM. Transient unilateral brachial plexopathy and partial Horner’s syndrome following spinal anaesthesia for caesarean section. J AnaesthesiolClinPharmacol. 2014;30:273-75
    [PubMed][Free full text]doi: 10.4103/0970-9185.130073.
  4. Myers RR, Sommer C. Methodology for spinal nurotoxicity studies. RegAnesth 1993;18 (6 Suppl):439-47
    [PubMed]